Fig. 4.

Infarct size is not affected by acute MAO inhibition in aged or aged OVX rats. Coronary artery ligation (CAL) was used to generate ischemia and reperfusion (I/R) injury (47 min I: 2 h R), with and without the MAO-A inhibitor clorgyline [5 mg/kg (black symbols) in aged (n = 5) or aged OVX (n = 3)] or 10 mg/kg clorgyline in aged (gray symbols; n = 3) administered 60 min (ip) prior to CAL. CAL studies were also performed using 35 min I: 2 h R in aged (n = 4) following 5 mg/kg clorgyline and no infarct sparing effect was observed (data not shown). Infarct size is expressed as a percentage of area at risk (AAR).