Table 3.
Genes altered in the lungs during hyperoxia exposure according to DNA microarray analysis
| Gene Name | Gene ID | Description | Fold Change |
|---|---|---|---|
| Mt3 | NM_053968 | metallothionein 3 | 4.50 |
| Lcn2 | X13295 | lipocalin 2 | 4.21 |
| C4a | U42719 | complement component 4a | 3.58 |
| Lgals3 | NM_031832 | lectin, galactose binding, soluble 3 | 3.60 |
| C1qb | NM_019262 | complement component 1, q subcomponent, beta polypeptide | 2.71 |
| Gpnmb | AF184983 | glycoprotein (transmembrane) nmb | 3.29 |
| Fabp5 | U13253 | fatty acid binding protein 5, epidermal | 2.38 |
| Ctgf | NM_022266 | connective tissue growth factor | 2.81 |
| Mapk13 | NM_019231 | mitogen activated protein kinase 13 | 2.43 |
| Clca2 | AF077303 | chloride channel calcium activated 2 | 2.43 |
| Atp1b1 | NM_013113 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 2.37 |
| Sod2 | NM_017051 | superoxide dismutase 2, mitochondrial | 2.61 |
| Basp1 | NM_022300 | brain abundant, membrane attached signal protein 1 | 2.25 |
| Retnla | NM_053333 | resistin like alpha | 4.12 |
| Actg2 | NM_012893 | actin, gamma 2 | 2.28 |
| Fetub | NM_053348 | fetuin beta | 2.85 |
| Prkaa2 | NM_023991 | protein kinase, AMP-activated, alpha 2 catalytic subunit | 2.00 |
| RS27 | X59375 | ribosomal protein s27 | 2.44 |
| Lr8 | AF370882 | LR8 protein | 2.00 |
| Des | NM_022531 | desmin | 2.04 |
| Sp4 | NM_012761 | Sp4 transcription factor | 2.01 |
| MT2 | M11794 | metallothionein 2 | 5.02 |
| S100 g | NM_012521 | S100 calcium binding protein G | 2.00 |
| Prdx1 | NM_057114 | peroxiredoxin 1 | 2.00 |
| Sftpd | NM_012878 | surfactant associated protein D | 2.15 |
| Ebf1 | NM_053820 | early B-cell factor 1 | 2.18 |
| Sept3 | AF111180 | septin 3 | 2.04 |
| S100a10 | NM_031114 | S100 calcium binding protein A10 (calpactin) | 2.07 |
| Homer1 | NM_031707_1 | Homer homolog 1 (Drosophila) | 1.96 |
| Gapdh | NM_017008_11 | glyceraldehyde-3-phosphate dehydrogenase | 2.12 |
| Vim | NM_031140 | vimentin | 2.16 |
| TIMP1 | NM_053819_1 | tissue inhibitor of metallopeptidase 1 | 2.16 |
| Pgk1 | NM_053291 | phosphoglycerate kinase 1 | 2.05 |
| IGF1 | M15650 | insulin-like growth factor 1 | 2.00 |
| Ldha | NM_017025 | lactate dehydrogenase A | 2.34 |
| Gstp2 | X02904 | glutathione S-transferase, pi 2 | 2.13 |
| Hpgd | NM_024390 | hydroxyprostaglandin dehydrogenase 15 (NAD) | 0.24 |
| DIDH | S57790 | 3 alpha-hydroxysteroid dehydrogenase | 0.26 |
| E41L1 | NM_021681_1 | hypothetical protein loc59317; rat brain 4.1 s; | 0.41 |
| Tas2r1 | NM_023993 | taste receptor, type 2, member 1 | 0.42 |
| Admr | NM_053302 | adrenomedullin receptor | 0.46 |
| Aoc3 | U72632 | amine oxidase, copper containing 3 | 0.45 |