Fig. 1.

Exercise training increased skeletal muscle citrate synthase activity and activity capacity in diabetes. A: citrate synthase activity levels determined in the soleus muscles of rats from all groups. The activity of mitochondrial oxidative enzyme was measured to mark the exercise training effect. The enzyme activity was expressed as 405-nm absorbance (A₄₀₅) per minute per milligram protein. Factorial (2 × 2) ANOVA interaction effect (health status × physical activity status) was not significant. B: activity capacity scores assigned to all four groups of rats after the cessation of exercise training. The scoring method was employed to complement the results from A and to partly determine the ability of metabolically active lean tissue to sustain an increased physical challenge in the presence of cardiac hypertrophy. Higher scores indicate better performance. Factorial (2 × 2) ANOVA interaction effect (health status × physical activity status) was significant (P = 0.001). NN, nonexercised nondiabetic; ND, nonexercised diabetic; EN, exercised nondiabetic; ED, exercised diabetic. Values are means ± SE. Significant difference from ^a NN, ^b ND, ^c EN, and ^d ED: P ≤ 0.05.