Table 2.
Echocardiographic assessment of left ventricular dimensions in wild-type and TNF-αTG mice before 4 wk of IH or IA exposure
| Wild-type IA | Wild-type IH | TNF-αTG IA | TNF-αTG IH | Strain Effect | IH Effect | Interaction | |
|---|---|---|---|---|---|---|---|
| Heart rate, beats/min | 487 ± 13 | 486 ± 16 | 475 ± 12 | 455 ± 20 | |||
| End diastolic dimension, mm | 0.354 ± 0.01 | 0.348 ± 0.011 | 0.454 ± 0.016 | 0.448 ± 0.015 | P < 0.001 | ||
| End systolic dimension, mm | 0.189 ± 0.01 | 0.189 ± 0.010 | 0.336 ± 0.017 | 0.326 ± 0.019 | P < 0.001 | ||
| Fractional shortening, % | 46.7 ± 2.0 | 45.5 ± 2.4 | 26.5 ± 1.4 | 28.0 ± 2.2 | P < 0.001 | ||
| Posterior wall thickness, mm | 0.097 ± 0.006 | 0.091 ± 0.010 | 0.083 ± 0.004 | 0.097 ± 0.012 | |||
| Ejection fraction, % | 83.1 ± 1.8 | 81.9 ± 2.2 | 58.0 ± 2.2 | 59.8 ± 3.4 | P < 0.001 | ||
| Sample size, n | 14 | 11 | 12 | 13 |
Values are means ± SE. Strain effect, IH effect, and interaction were determined by ANOVA. As expected, for data collected at this preexposure time point, there was no independent effect of IH or any interaction.