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. 2012 Sep 6;113(8):1184–1193. doi: 10.1152/japplphysiol.00098.2012

Fig. 1.

Fig. 1.

Phrenic hypoxic responses during episodes of hypoxia. Changes in phrenic burst amplitudes during 5-min of hypoxic exposures (average of 3 episodes) from rats that received spinal injections before acute intermittent hypoxia (AIH) or vehicle (siBuffer; n = 7), small interfering (si)RNAs targeting TrkB (siTrkB; n = 8), siRNA targetting brain-derived neurotrophic factor (siBDNF; n = 9), MEK inhibitor (U0126, n = 9), or phosphatidylinositol 3-kinase (PI3K) inhibitor (PI-828; n = 6) and rats that received post-AIH injections of vehicle (n = 8) and U0126 (n = 8) are shown. Phrenic burst amplitudes increased from baseline in all groups, although no between-group differences were detected. ∫Phr, integrated phrenic. Values are means ± SE. #Significantly ifferent from baseline (P < 0.05).