Table 1.

Measurements of Pa_CO2, Pa_O2, and MAP during baseline, hypoxia, and 60 min posthypoxia

	PaCO2, mmHg			PaO2, mmHg			MAP, mmHg
Treatment groups	Baseline	Hypoxia	60 min Posthypoxia	Baseline	Hypoxia	60 min Posthypoxia	Baseline	Hypoxia	60 min Posthypoxia
Pre-AIH
Vehicle	42.2 ± 0.4	41.6 ± 0.6	41.9 ± 0.4	242 ± 22	37 ± 2‡*	250 ± 10	120 ± 7	92 ± 11*	102 ± 8
Vehicle control	45.8 ± 0.8†	45.7 ± 1.3†	45.7 ± 1.0†	290 ± 11†	287 ± 9	276 ± 6	109 ± 9	109 ± 11	109 ± 12
siBDNF	46.1 ± 0.7†	46.3 ± 1.3†	45.8 ± 0.9†	285 ± 5	39 ± 3‡*	277 ± 6	81 ± 11	60 ± 6	77 ± 9
siTrkB	46.9 ± 0.5	43.6 ± 1.4*	47.4 ± 0.4†	292 ± 7	38 ± 1‡*	283 ± 4	85 ± 11	70 ± 8	81 ± 9
U0126	46.6 ± 0.9†	46.3 ± 0.9†	47.0 ± 1.2†	300 ± 10†	42 ± 2‡*	289 ± 15	111 ± 5	84 ± 10*	106 ± 5
PI-828	47.7 ± 1.4†	46.5 ± 1.4†	48.5 ± 1.2†	290 ± 15†	39 ± 1‡*	265 ± 21	106 ± 6	88 ± 7	95 ± 4

	Baseline	Hypoxia	60 min	Baseline	Hypoxia	60 min	Baseline	Hypoxia	60 min
Post-AIH
Vehicle	46.9 ± 2.0	49.0 ± 3.0	46.7 ± 2.3	266 ± 18	36 ± 2*	279 ± 12	109 ± 5	65 ± 13*	90 ± 6
U0126	48.2 ± 1.1	47.0 ± 1.7	48.3 ± 1.4	265 ± 13	68 ± 2*	255 ± 7	118 ± 7	90 ± 7	84 ± 9
Vehicle control	47.5 ± 1.8	46.6 ± 1.6	46.3 ± 1.9	262 ± 19	261 ± 23	262 ± 16	106 ± 7	100 ± 9	99 ± 9
U0126 control	47.4 ± 2.0	46.3 ± 1.2	47.3 ± 1.4	296 ± 8	295 ± 11	294 ± 8	112 ± 6	102 ± 5	85 ± 8

Values are means ± SE. Pa_CO2, arterial Pco₂; Pa_O2, arterial Po₂; MAP, mean arterial pressure; AIH, acute intermittent hypoxia; siBDNF, small interfering (si)RNA targeting brain-derived neurotrophic factor; siTrkB, siRNA targeting TrkB.

^*Significantly different than baseline;

^†significantly different than vehicle (with AIH);

^‡significantly different than vehicle (without AIH) (P < 0.05).