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. 2012 Jun 21;113(8):1332–1341. doi: 10.1152/japplphysiol.00522.2012

Fig. 3.

Fig. 3.

Cardiac function and the sympathetic support of cardiac function in intact and T5X rats. Effects of midthoracic SCI and beta-adrenergic receptor blockade on dP/dt+ (A) and dP/dt− (B) in 10 intact male rats. Following the experimental procedures in the intact condition (weeks 1 and 2), 6 of the 10 rats were subjected to T5 spinal cord transection, and the remaining 4 rats were subjected to sham T5X (indicated by the arrow) and were subsequently studied 1, 3, 7, 14, and 21 days postsurgery. Without beta blockade, dP/dt+ and dP/dt− were not different between sham-operated intact and T5X rats. Beta-adrenergic receptor blockade lowered dP/dt+ and dP/dt− in rats with SCI only, and importantly, dP/dt+ and dP/dt− were lower in rats with SCI compared with sham-operated intact rats after beta-adrenergic receptor blockade, documenting LV dysfunction. *P < 0.05, intact vs. T5X; #P < 0.05, no drug vs. β-x.