Figure 1. GSPE treatment reduces motor deficits in JNPL3 mice.
(A) Body weight in untreated (n=9) and GSPE-treated (n=7) JNPL3 mice following 6 months of treatment. Arrow indicates the initiation of GSPE treatment in JNPL3mice at approximately 9 months of age. Mean values ± SEM. One-way ANOVA showed no significant differences between the groups. (B) Wire hang test assessed in untreated (n=9) and 6-months GSPE treated (n=7) animals at 15 months of age. Results presented as scatter plots and means. GSPE-treatment improved the test scores from 6 sec to 26 sec at p= 0.0368 using one-tailed Mann Whitney t-test for non-parametric data distribution.