Table 1.
Linear contrasts between event types for the placebo and the alcohol sessions.
| Comparison | Treatment | Cluster size | x | y | z | t-score | Brain region |
|---|---|---|---|---|---|---|---|
| Choice: | |||||||
| Risky > safe | Placebo | No clusters detected | |||||
| Alcohol | 295 | −9 | −57 | 42 | 4.55 | L. cingulate/precuneus | |
| 156 | 19 | 33 | 2 | 6.17 | R. caudate/anterior cingulate | ||
| 91 | −7 | 15 | 8 | 5.13 | L. caudate | ||
| Interaction | 339 | 19 | −33 | 4 | 6.37 | R. anterior cingulate/caudate | |
| 265 | −17 | 27 | 12 | 4.66 | L. anterior cingulate/caudate | ||
| 208 | −1 | −79 | 40 | 5.51 | L. precuneus | ||
| 140 | 7 | −59 | 48 | 4.16 | R. precuneus | ||
| 109 | 37 | −53 | 6 | 4.3 | R. middle temporal gyrus | ||
| Anticipation: | |||||||
| Risky > safe | Placebo | 297 | −43 | −45 | 38 | −5.71 | L. inferior parietal |
| 265 | 39 | 33 | 34 | −6.86 | R. middle frontal gyrus | ||
| 234 | −35 | 33 | 24 | −5.59 | L. middle frontal gyrus | ||
| Alcohol | 158 | 41 | −73 | 20 | −7.38 | R. middle temporal gyrus | |
| 80 | 27 | −43 | 42 | −5.36 | R. precuneus | ||
| Interaction | 83 | −31 | −57 | 30 | 4.78 | L. middle temporal gyrus | |
| Feedback: | |||||||
| Win > safe | Placebo | 4150 | −25 | 25 | 2 | 12.02 | Caudate/putamen/thalamus |
| 2768 | −35 | −53 | 44 | 7.28 | L. inferior parietal/precuneus | ||
| 394 | 3 | −67 | −14 | 9.18 | R. lingual gyrs | ||
| 239 | −43 | 7 | 18 | 5.09 | L. insula | ||
| 163 | −39 | 23 | 34 | 5.55 | L. precuneus | ||
| 133 | −25 | −5 | 48 | 5.6 | L. middle frontal gyrus | ||
| 99 | 27 | −5 | 48 | 4.95 | R. middle frontal gyrus | ||
| Alcohol | No clusters detected | ||||||
| Interaction | 3612 | −1 | −27 | 8 | 9.71 | Bilateral thalamus/caudate | |
| 156 | −13 | 9 | −10 | 5.64 | L. nucleus accumbens | ||
| 106 | 23 | 55 | 18 | 4.43 | R. middle frontal gyrus | ||
| 91 | −59 | −39 | 38 | 4.6 | L. inferior parietal lobule | ||
| Loss > safe | Placebo | 1292 | 11 | 31 | 30 | 9.49 | R. medial frontal/cingulate |
| 1051 | 31 | 23 | 6 | 8.88 | R. insula | ||
| 679 | −29 | 19 | 6 | 8.79 | L. insula | ||
| 334 | 19 | 5 | 36 | −7.07 | R. cingulate | ||
| 121 | −3 | −15 | −8 | 5.20 | L. thalamus | ||
| Alcohol | No clusters detected | ||||||
| Interaction | 346 | 29 | 15 | −8 | 5.29 | R. insula | |
| Win > loss | Placebo | 3510 | 33 | −49 | 16 | 5.14 | R. superior temporal gyrus |
| 794 | 17 | −11 | 44 | 5.64 | R. cingulate | ||
| 639 | −31 | −31 | 46 | 5.73 | L. postcentral gyrus | ||
| 567 | −41 | 47 | 10 | 5.17 | L. middle frontal gyrus | ||
| 381 | −7 | 33 | 28 | 4.35 | L. cingulate | ||
| 247 | −11 | 7 | −12 | 5.65 | L. nucleus accumbens | ||
| 191 | 11 | 13 | −14 | 5.80 | R. nucleus accumbens | ||
| 186 | −49 | −49 | −14 | 4.78 | L. fusiform gyrus | ||
| 145 | −13 | 41 | −14 | 3.90 | L. medial frontal gyrus | ||
| Alcohol | No clusters detected | ||||||
| Interaction | No clusters detected | ||||||
Activations thresholded at P < 0.005, uncorrected with a cluster size k ≥ 80 voxels, yielding a corrected value of P < 0.05. Coordinates refer to the Talairach system.