FIG. 2.

Vector transduction monitored by Cre modification of three reporter genes. (A) Diagram of Cre-induced reporter activation in hybrid mice after vector administration. One luciferase and one mT/mG cassette depict the presence of exactly one of each target gene per cell in these heterozygous mice. (B) Luciferase imaging and signal quantification in female hybrid mice injected by the intravenous route with the indicated amounts of scAAV9-Cre 18 days after injection. (C) Confocal images of liver tissue sections from the same mice harvested on day 18. Tissues are counterstained for nuclei with DAPI. Original magnification, ×630.