Fig. 1.
Overview of the p73 DBD structure. (a) Ribbon representation of the 1.8‐Å crystal structure of the human p73 DBD, highlighting the different secondary structural elements. The remaining portion of the C-terminal TEV cleavage site is colored gray. Bound zinc ions are shown as blue spheres. (b) Multiple sequence alignment of the p53 family DBD generated with Clustal W and visualized with JalView.26 Filled triangles indicate the positions of conserved DNA contact residues. Structure image was generated with PyMOL.