Table 2a. The top 50 unique genes upregulated in lesional skin compared with non-lesional skin biopsy samples obtained at baseline from 85 patients with moderate-to-severe psoriasis (FDR P<0.05 and FCH >2).

				Mean expression in skin samples
Probe set ID	Gene symbol	Gene title	Fold change (lesional vs. non-lesional)	Non- lesional	Lesional	Cytokine regulation1
205863_at	S100A12	S100 calcium–binding protein A12	889.1	2.72	12.52	IL-17, TNF-α, IFN-γ, A
211906_s_at	SERPINB4	Serpin peptidase inhibitor, clade B (ovalbumin), member 4	740.44	3.76	13.30	IL-17, S
205513_at	TCN1	Transcobalamin I (vitamin B12–binding protein, R binder family)	400.17	2.95	11.60
232220_at	S100A7A	S100 calcium–binding protein A7A	287.22	5.15	13.32	S
220664_at	SPRR2C	Small proline-rich protein 2C (pseudogene)	243.3	3.62	11.55	IL-17, A
205660_at	OASL	2′-5′-Oligoadenylate synthetase-like	238.28	3.15	11.04	IFN-γ
207602_at	TMPRSS11D	Transmembrane protease, serine 11D	199.6	2.89	10.53	S
1569555_at	GDA	Guanine deaminase	168.79	3.44	10.84
210663_s_at	KYNU	Kynureninase (L-kynurenine hydrolase)	153.53	2.75	10.02	TNF-α, S
207367_at	ATP12A	ATPase, H+/K+ transporting, nongastric, α-polypeptide	148.59	3.93	11.15	A
220528_at	VNN3	Vanin 3	144.45	2.23	9.40	S
210413_x_at	SERPINB3/SERPINB4	Serpin peptidase inhibitor, clade B (ovalbumin), member 3/serpin peptidase inhibitor, clade B (ovalbumin), member 4	136.5	6.86	13.95
206561_s_at	AKR1B10	Aldo-keto reductase family 1, member B10 (aldose reductase)	114.33	6.19	13.03
202859_x_at	IL8	interleukin 8	105.05	2.82	9.54	IL-17, TNF-α, S
205783_at	KLK13	Kallikrein-related peptidase 13	94.62	4.16	10.73
219554_at	RHCG	Rh family, C glycoprotein	74.17	5.51	11.72	IL-17, TNF-α, A
204470_at	CXCL1	Chemokine (C–X–C motif) ligand 1 (melanoma growth stimulating activity, alpha)	72.33	2.45	8.63	IL-17, TNF-α, IFN-γ, S
1554914_at	PLA2G4D	Phospholipase A2, group IVD (cytosolic)	66.91	2.75	8.81
205476_at	CCL20	Chemokine (C–C motif) ligand 20	64.89	2.93	8.95	IL-17, TNF-α, S
219403_s_at	HPSE	Heparanase	63.46	6.14	12.13
216258_s_at	SERPINB13	Serpin peptidase inhibitor, clade B (ovalbumin), member 13	61.38	3.25	9.19
210164_at	GZMB	Granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	60.46	2.93	8.85
232074_at	PRSS27	Protease, serine 27	56.4	4.33	10.15
204733_at	KLK6	Kallikrein-related peptidase 6	51.71	6.79	12.48
205844_at	VNN1	Vanin 1	50.72	4.41	10.08
210038_at	PRKCQ	Protein kinase C, theta	48.3	2.54	8.14
206912_at	FOXE1	Forkhead box E1 (thyroid transcription factor 2)	46.38	2.92	8.45	S
239430_at	IGFL1	IGF-like family member 1	46.06	4.77	10.30
220322_at	IL1F9	Interleukin 1 family, member 9	45.99	7.82	13.34	IL-17, TNF-α, IFN-γ, A
209719_x_at	SERPINB3	Serpin peptidase inhibitor, clade B (ovalbumin), member 3	45.81	8.96	14.48	IFN-γ(−), S
212531_at	LCN2	Lipocalin 2	45.74	7.96	13.47	IL-17, TNF-α, IFN-γ(−), A
224204_x_at	ARNTL2	Aryl hydrocarbon receptor nuclear translocator-like 2	43.67	4.03	9.48
213797_at	RSAD2	Radical S-adenosyl methionine domain containing 2	41.39	5.03	10.40	IFN-γ
233504_at	C9orf84	Chromosome 9 open reading frame 84	40.75	3.70	9.05
227735_s_at	C10orf99	Chromosome 10 open reading frame 99	40.71	7.78	13.13
203535_at	S100A9	S100 calcium–binding protein A9	40.71	9.25	14.60	IL-17, TNF-α, IFN-γ, A
226698_at	FCHSD1	FCH and double SH3 domains 1	39.37	5.42	10.72
220249_at	HYAL4	Hyaluronoglucosaminidase 4	39.25	4.25	9.55
202134_s_at	WWTR1	WW domain containing transcription regulator 1	36.95	4.69	9.89	TNF-α(−), IFN-γ(−)
206134_at	ADAMDEC1	ADAM-like, decysin 1	36.28	4.32	9.50
241994_at	XDH	Xanthine dehydrogenase	35.21	3.41	8.55	IFN-γ
1553434_at	CYP4Z2P	Cytochrome P450, family 4, subfamily Z, polypeptide 2 pseudogene	34.49	2.22	7.33
227609_at	EPSTI1	Epithelial stromal interaction 1 (breast)	34.32	3.77	8.87
206008_at	TGM1	Transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-γ-glutamyltransferase)	34.05	5.62	10.71	TNF-α, IFN-γ, A
219691_at	SAMD9	Sterile α-motif domain containing 9	33.57	4.43	9.50	IFN-γ
240304_s_at	TMC5	Transmembrane channel-like 5	33.52	3.11	8.18
221107_at	CHRNA9	Cholinergic receptor, nicotinic, α-9	32.35	3.19	8.21
204465_s_at	INA	Internexin neuronal intermediate filament protein, alpha	31.67	3.85	8.83
239586_at	FAM83A	Family with sequence similarity 83, member A	31.29	5.43	10.40
209773_s_at	RRM2	Ribonucleotide reductase M2 polypeptide	31.19	5.71	10.67	IFN-γ(−)

Abbreviations: FCH, fold change; FDR, false discovery rate; TNF, tumor necrosis factor.

¹Genes that are induced by IL-17, IFN-γ, and TNF-α in keratinocytes and yield a synergistic (S) or additive (A) effect between IL-17 and TNF on keratinocytes (Nograles et al., 2008; Chiricozzi et al., 2011).