Table 2b. The top 50 unique genes downregulated in lesional skin compared with non-lesional skin biopsy samples obtained at baseline from 85 patients with moderate-to-severe psoriasis (FDR P<0.05 and FCH>2).
|
Mean expression in skin samples |
||||||
|---|---|---|---|---|---|---|
| Probe set ID | Gene symbol | Gene title | Fold change (lesional vs. non-lesional) | Non- lesional | Lesional | Cytokine regulation1 |
| 217059_at | MUC7 | Mucin 7, secreted | −26.11 | 7.62 | 2.91 | |
| 241412_at | BTC | Betacellulin | −25.6 | 7.59 | 2.91 | |
| 205404_at | HSD11B1 | Hydroxysteroid (11-β) dehydrogenase 1 | −24.61 | 9.23 | 4.61 | TNF-α, IFN-γ |
| 205979_at | SCGB2A1 | Secretoglobin, family 2A, member 1 | −22.46 | 9.23 | 4.74 | |
| 229477_at | THRSP | Thyroid hormone responsive (SPOT14 homolog, rat) | −22.24 | 8.64 | 4.16 | |
| 204712_at | WIF1 | WNT inhibitory factor 1 | −21.11 | 9.21 | 4.81 | |
| 214053_at | ERBB4 | V-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) | −17.98 | 6.85 | 2.68 | |
| 227174_at | WDR72 | WD repeat domain 72 | −17.24 | 7.17 | 3.07 | |
| 205883_at | ZBTB16 | Zinc-finger and BTB domain containing 16 | −16.84 | 8.06 | 3.98 | |
| 208962_s_at | FADS1/FADS3 | Fatty acid desaturase 1/fatty acid desaturase 3 | −15.95 | 9.84 | 5.84 | IFN-γ(−) |
| 229151_at | SLC14A1 | Solute carrier family 14 (urea transporter), member1 (Kidd blood group) | −15.86 | 7.46 | 3.47 | |
| 204607_at | HMGCS2 | 3-Hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) | −15.36 | 8.08 | 4.14 | |
| 207430_s_at | MSMB | Microseminoprotein, β- | −13.47 | 6.99 | 3.24 | |
| 239929_at | PM20D1 | Peptidase M20 domain containing 1 | −13.28 | 10.05 | 6.32 | |
| 214240_at | GAL | Galanin prepropeptide | −12.5 | 7.35 | 3.71 | TNF-α(−), IFN-γ(−) |
| 1559097_at | C14orf64 | Chromosome 14 open reading frame 64 | −11.89 | 6.35 | 2.78 | |
| 230197_s_at | TPPP | Tubulin polymerization promoting protein | −11.11 | 9.72 | 6.24 | |
| 205325_at | PHYHIP | Phytanoyl-CoA 2-hydroxylase interacting protein | −10.28 | 8.44 | 5.08 | |
| 234980_at | TMEM56 | Transmembrane protein 56 | −10.27 | 6.22 | 2.86 | |
| 235278_at | MACROD2 | MACRO domain containing 2 | −9.55 | 6.34 | 3.08 | |
| 205029_s_at | FABP7 | Fatty acid–binding protein 7, brain | −9.42 | 9.31 | 6.07 | |
| 220801_s_at | HAO2 | Hydroxyacid oxidase 2 (long chain) | −9.39 | 5.75 | 2.52 | |
| 205030_at | FABP7 | Fatty acid–binding protein 7, brain | −9.29 | 10.33 | 7.12 | |
| 213920_at | CUX2 | Cut-like homeobox 2 | −9.26 | 5.93 | 2.72 | |
| 1555318_at | HIF3A | Hypoxia-inducible factor 3, α-subunit | −9.25 | 10.45 | 7.24 | |
| 221795_at | NTRK2 | Neurotrophic tyrosine kinase, receptor, type 2 | −9.22 | 8.41 | 5.20 | |
| 234513_at | ELOVL3 | Elongation of very long-chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3 | −9.21 | 5.84 | 2.64 | |
| 201596_x_at | KRT18 | Keratin 18 | −9.17 | 8.60 | 5.40 | |
| 227803_at | ENPP5 | Ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative function) | −8.93 | 6.45 | 3.29 | |
| 208331_at | BPY2 | Basic charge, Y-linked, 2 | −8.8 | 6.03 | 2.89 | |
| 222102_at | GSTA3 | Glutathione S-transferase A3 | −8.75 | 10.04 | 6.91 | |
| 223836_at | FGFBP2 | Fibroblast growth factor–binding protein 2 | −8.65 | 9.48 | 6.37 | |
| 213661_at | DKFZP586H2123 | Regeneration-associated muscle protease | −8.64 | 10.15 | 7.04 | |
| 232602_at | WFDC3 | WAP four-disulfide core domain 3 | −8.62 | 8.27 | 5.16 | |
| 201650_at | KRT19 | Keratin 19 | −8.35 | 10.67 | 7.61 | TNF-α, IFN-γ |
| 239246_at | FARP1 | FERM, RhoGEF (ARHGEF), and pleckstrin domain protein 1 (chondrocyte-derived) | −8.26 | 8.59 | 5.55 | TNF-α |
| 231859_at | C14orf132 | Chromosome 14 open reading frame 132 | −8.18 | 7.33 | 4.30 | |
| 207955_at | CCL27 | Chemokine (C–C motif) ligand 27 | −8.14 | 12.55 | 9.52 | TNF-α |
| 1564786_at | LOC338667 | Hypothetical protein LOC338667 | −7.82 | 7.36 | 4.40 | |
| 1557474_at | LOC284578 | Hypothetical protein LOC284578 | −7.81 | 5.66 | 2.69 | |
| 214598_at | CLDN8 | Claudin 8 | −7.67 | 10.82 | 7.88 | |
| 204416_x_at | APOC1 | Apolipoprotein C-I | −7.62 | 10.28 | 7.35 | |
| 231535_x_at | ROPN1 | Ropporin, rhophilin-associated protein 1 | −7.58 | 6.59 | 3.66 | |
| 239304_at | MFSD4 | Major facilitator superfamily domain containing 4 | −7.43 | 7.42 | 4.53 | |
| 204032_at | BCAR3 | Breast cancer anti-estrogen resistance 3 | −7.37 | 8.00 | 5.11 | |
| 220425_x_at | ROPN1/ROPN1B | Ropporin, rhophilin-associated protein 1/ropporin, rhophilin associated protein 1B | −7.28 | 7.82 | 4.96 | |
| 224646_x_at | H19 | H19, imprinted maternally expressed transcript | −7.19 | 11.01 | 8.16 | |
| 205529_s_at | RUNX1T1 | Runt-related transcription factor 1; translocated to, 1 (cyclin D-related) | −7.1 | 8.10 | 5.27 | |
| 228943_at | MAP6 | Microtubule-associated protein 6 | −7.08 | 5.61 | 2.79 | |
| 1560741_at | SNRPN | Small nuclear ribonucleoprotein polypeptide N | −7.06 | 6.85 | 4.03 | |
Abbreviations: FCH, fold change; FDR, false discovery rate; TNF, tumor necrosis factor.
1
Genes that are induced by IFN-γ or TNF-α on keratinocytes (Nograles et al., 2008).