Table 4. Increased expression of 12 proteins, as detected by serum and gene microarray assessments, in psoriasis patients (n=146) versus a control population of healthy individuals (n=162).
|
Serum measurements |
Gene array measurements |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Symbol | Name | P-value1 | Fold change (psoriasis vs. healthy controls) | Healthy controls (n=162) | Psoriasis patients (n=146) | Psoriasis patients with BMI2 <30 (n=75) | Psoriasis patients with BMI2 ⩾30 (n=73) | Fold change (lesional vs. non-lesional) | P-value | False discovery rate | Non- lesional skin | Lesional skin |
| S100A12 | ENRAGE | 4.06 × 10−26 | 2.30 | 25.46 | 58.55 | 55.94 | 60.22 | 889.1 | <10−20 | <10−20 | 2.72 | 12.52 |
| ACPP | Prostatic acid phosphatase | 1.17 × 10−35 | 2.50 | 0.20 | 0.49 | 0.46 | 0.51 | 8.3 | <10−20 | <10−20 | 8.87 | 11.92 |
| CCL22 | MDC | <10−50 | 3.03 | 409.31 | 1240.06 | 1227.13 | 1211.61 | 3.91 | 1.11 × 10−16 | 1.18 × 10−15 | 8.93 | 10.90 |
| IL1RN | IL1RA | 5.67 × 10−32 | 2.65 | 68.97 | 182.84 | 138.65 | 223.63 | 3.03 | 2.86 × 10−11 | 1.65 × 10−10 | 3.93 | 5.53 |
| TNPO1 | MIP1β | 1.52 × 10−39 | 2.34 | 131.53 | 307.87 | 299.36 | 314.43 | 2.82 | <10−20 | <10−20 | 8.51 | 10.01 |
| CCL2 | MCP1 | <10−40 | 3.55 | 141.20 | 501.78 | 491.29 | 509.71 | 2.47 | <10−20 | <10−20 | 10.39 | 11.70 |
| VEGFA | VEGF | 1.74 × 10−29 | 1.83 | 449.19 | 821.76 | 859.10 | 794.82 | 1.99 | 9.76 × 10−13 | 6.61 × 10−12 | 8.86 | 9.85 |
| ICAM1 | ICAM1 | 1.67 × 10−05 | 1.26 | 134.07 | 169.41 | 153.51 | 184.43 | 1.84 | 7.74 × 10−08 | 3.17 × 10−07 | 6.68 | 7.56 |
| IL15 | IL-15 | 8.80 × 10−06 | 1.25 | 0.65 | 0.81 | 0.80 | 0.81 | 1.84 | 1.85 × 10−09 | 8.86 × 10−09 | 6.69 | 7.57 |
| TNFRSF1B | TNF-RII | 7.32 × 1018 | 1.40 | 3.50 | 4.91 | 4.60 | 5.21 | 1.53 | 5.45 × 10−08 | 2.26 × 10−07 | 8.94 | 9.55 |
| TNF | TNFα | <10−50 | 2.50 | 3.54 | 8.85 | 8.37 | 9.31 | 1.453 | 1.25 × 10−08 | 5.51 × 10−08 | 3.11 | 3.65 |
| CXCL5 | ENA78 | 1.40 × 10−45 | 3.04 | 0.75 | 2.29 | 2.08 | 2.48 | 1.144 | 3.25 × 10−02 | 6.28 × 10−02 | 2.25 | 2.44 |
Abbreviations: BMI, body mass index; FDR, false discovery rate; RT-PCR, real-time reverse transcriptase PCR.
1
P-values were adjusted to control the FDR and all resulted in FDR <0.05.
2
BMI defined as baseline BMI <30 includes normal and overweight patients; BMI defined as baseline BMI ⩾30 includes obese patients.
3
TNF has previously been reported to be increased in psoriatic lesional skin when assessed via by RT-PCR (Suárez Fariñas et al., 2010).
4
CXCL5/ENA78 has previously been reported to be increased in psoriatic lesional skin (Zhou et al., 2003).