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. 2012 Nov 1;139(21):4062–4071. doi: 10.1242/dev.082321

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Fig. 3. — The pMN expansion is restored over time when Arl13b is deleted at E9.25 and E9.5. (A-D) Olig2 (red) and HB9 (green) cells are expressed in the pMN domain of control at E10.5 (A), but are expanded in Arl13b^hnn (B), Arl13b^Δ^E9.25 (C) and Arl13b^Δ^E9.5 (D). (E-H) Shh (green) is expressed in the notochord and the floor plate of E10.5 control (E) and Arl13b^Δ^E9.5 (H), but only in the notochord of Arl13b^hnn (F) and Arl13b^Δ^E9.25 (G). (I-L) At E12.5, there is normal Olig2 (red) and HB9 (green) expression in control (I) and Arl13b^Δ^E9.5 (L), whereas there is an expansion of cells in Arl13b^hnn caudal neural tube (J). Olig2 and HB9 cells are mainly in their correct domains in Arl13b^Δ^E9.25, except that there are some dorsally expressed Olig2 and HB9 cells (K and white arrows). (M-P) In control (M), Arl13b^Δ^E9.25 (O) and Arl13b^Δ^E9.5 (P) caudal neural tube, Shh is expressed in the notochord and floor plate at E12.5, whereas it is expressed in only the notochord of Arl13b^hnn neural tube (N). (Q) Quantitative results showing that the percentage of normalized Olig2 (red) and HB9 (green) cells in E12.5 Arl13b^Δ^E9.25 and Arl13b^Δ^E9.5 caudal neural tube are similar to control, whereas there are excessive Olig2 and HB9 cells in Arl13b^hnn. Data are mean±s.d. *P<0.05.