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. 2012 Nov 1;139(21):3973–3985. doi: 10.1242/dev.081596

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© 2012.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.

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Fig. 7. — Erg^Δ^Ex4/^Δ^Ex4 embryos display hemorrhages and disrupted vasculature. (A-D) Whole-mount images of Erg^+/+ and Erg^ΔEx4/ΔEx4 mouse embryos at E10.5. Erg^ΔEx4/ΔEx4 embryos are growth retarded (B-D) and show hemorrhages (arrows in B-D) when compared with controls (A). (E,F) CD31 whole-mount immunohistochemistry of head of Erg^+/+ (E) and Erg^ΔEx4/ΔEx4 (F) embryos at E10.5. (G-J) Magnified images of the boxed regions in E and F. Note the well-connected minor branches in the controls (G), whereas the mutants display a disorganized pattern of vasculature (H). (I) Wild-type embryo showing a segmented pattern of intersomitic vessels and capillary network, as compared with the severe disorganization of intersomitic vessels and reduced capillary network in Erg^ΔEx4/ΔEx4 embryos (J). (K,L) E10.5 Erg^ΔEx4/ΔEx4 embryo revealing pericardial effusion (K); the boxed region is magnified in L (arrow points to the effusion).