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. 2012 Nov 1;139(21):3973–3985. doi: 10.1242/dev.081596

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© 2012.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.

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Fig. 8. — Placental vascular defects in Erg^Δ^Ex4/^Δ^Ex4 embryos at E10. (A,B) The dashed lines in Erg^+/+ (A) and Erg^ΔEx4/ΔEx4 (B) indicate the extent of decidual invasion in each placental section. (C,D) Magnification of the boxed areas in A and B. Well-defined vasculature is observed in Erg^+/+ placentas (C), whereas the mutants, although they have abundant maternal blood sinuses, lack well-defined fetal-derived capillaries (D). (E,F) Higher magnification of C and D reveal abundant nucleated fetal blood in the controls (arrows, E), whereas the mutants show a drastic reduction in the number of fetal blood cells and exhibit collapsed capillaries (arrows, F). D, maternal decidua; L, labyrinth; E, embryo; MB, maternal blood; EB, embryonic blood.