. 2012 Oct;62(5):348–360.

Table 6.

Selected serum chemistry parameters in mice after 25 d of corticosterone treatment

	Dose of corticosterone (μg/mL)
	0	25	50	100
ALT (U/L)	48.6 (n = 10)^a	4.1 (n = 12)^a	52.1 (n = 11)^a,b	156.0 (n = 12)^b
AST (U/L)	116.5 (n = 10)^a	41.7 (n = 12)^a	67.9 (n = 11)^a,b	123.5 (n = 12)^b
Albumin (g/dL)	2.9 (n = 10)^a	15.5 (n = 12)^b	35.0 (n = 11)^c	41.4 (n = 12)^c
Globulin (g/dL)	2.4 (n = 10)^a	22.0 (n = 10)^b	20.0 (n = 11)^b	19.6 (n = 12)^b
Total bilirubin (mg/dL)	0.21 (n = 10)^a	−0.8 (n = 12)^a	25.5 (n = 11)^a,b	38.9 (n = 12)^b
ALP (U/L)	92.7 (n = 10)^a	−27.3 (n = 12)^b	−30.8 (n = 11)^b	−32.7 (n = 12)^b
Glucose (mg/dL)	238.3 (n = 9)^a	−15.0 (n = 10)^a	−3.1 (n = 11)^a	45.8 (n = 12)^b
Cl (mEq/L)	107.8 (n = 10)^a	−1.0 (n = 12)^a	−1.9 (n = 11)^a	−6.3 (n = 12)^b
Na (mEq/L)	151.6 (n = 10)^a	2.1 (n = 12)^b	2.0 (n = 11)^b,c	0.3 (n = 12)^a,c
Ca (mg/dL)	10.0 (n = 9)^a	1.1 (n = 11)^a,b	7.0 (n = 11)^b,c	8.0 (n = 12)^c
K (mEq/L)	7.8 (n = 10)^a	−3.0 (n = 12)^a	−5.5 (n = 11)^a	−6.5 (n = 12)^a
Anion gap (mEq/L)	24.7 (n = 10)^a	24.8 (n = 11)^b	21.6 (n = 11)^b	33.2 (n = 12)^b
Total CO₂ (mEq/L)	26.9 (n = 10)^a	−7.1 (n = 11)^a	−2.3 (n = 11)^a	−5.2 (n = 12)^a
Osmolity (mOsm/kg)	288.4 (n = 10)^a	11.3 (n = 10)^a	12.2 (n = 11)^a	11.9 (n = 12)^a
Cholesterol (mg/dL)	86.2 (n = 10)^a	33.0 (n = 12)^b	68.1 (n = 11)^c	70.5 (n = 12)^c
Triglycerides (mg/dL)	99.3 (n = 3)^a	41.0 (n = 8)^a	97.0 (n = 7)^a,b	167.9 (n = 8)^b

Values for control (0 μg/mL) group expressed as mean values for each analyte; values for treated (25, 50, and 100 μg/mL) groups expressed as % difference ([mean treated value − mean control]/mean control × 100%) from control value. One-way ANOVA with post hoc Tukey multiple comparison tests were used to compared samples with control (0 μg/mL corticosterone, 1% ethanol) values. For each parameter, values with different superscript letters are significantly (P < 0.05) different from each other.