. 2012 Oct;62(5):348–360.

Table 7.

Selected serum chemistry parameters in mice after 25 d of corticosterone treatment followed by a 14-d recovery period

	Dose of corticosterone (μg/mL)
	0	25	50	100
ALT (U/L)	47.5 (n = 4)^a	46.6 (n = 8)^a	−8.6 (n = 7)^a	−12.1 (n = 8)^a
AST (U/L)	137.8 (n = 4)^a	48.7 (n = 8)^a	−14.6 (n = 7)^a	7.0 (n = 8)^a
Albumin (g/dL)	2.9 (n = 4)^a	6.1 (n = 8)^a	5.8 (n = 7)^a	−1.8 (n = 8)^a
Globulin (g/dL)	2.9 (n = 4)^a	−12.6 (n = 8)^a,b	−21.5 (n = 7)^b	−17.8 (n = 8)^b
Total bilirubin (mg/dL)	0.20 (n = 4)^a	25.0 (n = 8)^a	7.1 (n = 7)^a	25.0(n = 8)^a
ALP (U/L)	97.5(n = 4)^a	34.5 (n = 8)^a	20.3 (n = 7)^a	17.2 (n = 8)^a
Glucose (mg/dL)	214.4 (n = 4)^a	−3.5 (n = 8)^a	−10.0 (n = 7)^a	−4.6 (n = 8)^a
Cl (mEq/L)	108.5 (n = 4)^a,b	0.0 (n = 8)^a	0.5 (n = 7)^a,b	2.6 (n = 8)^b
Na (mEq/L)	153.8 (n = 4)^a	1.4 (n = 8)^a	0.6 (n = 7)^a	−0.1 (n = 8)^a
Ca (mg/dL)	10.1 (n = 4)^a	0.4 (n = 8)^a	0.1 (n = 7)^a	−0.9 (n = 8)^a
K (mEq/L)	7.9 (n = 4)^a	−1.6 (n = 8)^a	−0.7 (n = 7)^a	0.8 (n = 8)^a
Anion gap (mEq/L)	25.9 (n = 4)^a,b	15.4 (n = 8)^a	13.6 (n = 7)^a,b	−5.5 (n = 8)^b
Total CO₂ (mEq/L)	27.3 (n = 4)^a	−7.3 (n = 8)^a	−11.4 (n = 7)^a	−5.5 (n = 8)^a
Osmolity (mOsm/kg)	320.1 (n = 4)^a	0.9 (n = 8)^a	0.0 (n = 7)^a	−0.7 (n = 8)^a
Cholesterol (mg/dL)	82.3 (n = 4)^a	16.7 (n = 8)^a,b	22.6 (n = 7)^b	8.2 (n = 8)^a,b
Triglycerides (mg/dL)	68.0 (n = 4)^a	−11.8 (n = 4)^a	59.9 (n = 7)^b	42.4 (n = 8)^c

Values for control (0 μg/mL) group expressed as mean values for each analyte; values for treated (25, 50, and 100 μg/mL) groups expressed as % difference ([mean treated value − mean control]/mean control × 100%) from control value. One-way ANOVA with post hoc Tukey multiple comparison tests were used to compared samples with control (0 μg/mL corticosterone, 1% ethanol) values. For each parameter, values with different superscript letters are significantly (P < 0.05) different from each other.