Table 3.

Statistical analysis of the effects of viral genetic variation and route of inoculation on titers of SV40 antibody responses in tumor-free hamsters

				Statistical analysis of antibody-positive sera
Group	Route of inoculation	Virus strain	No. of positive sera analyzed	Groups compared			P
SV40 T-antigen IgG
1	IC	776-2E	10	All viruses, IV+IC (groups 1, 2, 3, 4, 5, 6; 51% positive a)	vs	All viruses, IP (groups 7, 8, 9, 10, 11; 62% positive a)	0.27
2		SVCPC	12
3	IV	SVCPC	2	2E viruses, IV+IC (groups 1, 4, 5, 6; 56% positive)	vs	2E viruses, IP (groups 7, 10, 11; 62% positive)	0.29
4		VA45-54	2
5		776-VA	4
6		776-CPC	11
				1E viruses, IV+IC (groups 2, 3; 43% positive)	vs	1E viruses, IP (groups 8,9; 62% positive)	0.27
7	IP (total)b	776-2E	35	2E viruses, IP (groups 7, 10, 11; 62% positive)	vs	1E viruses, IP (groups 8, 9; 62% positive)	0.99
8		SVCPC	17
9		SVCPC-776	4
10		VA45-54	6
11		776-VA	9
				2E viruses, IV+IC (groups 1, 4, 5, 6; 56% positive)	vs	1E viruses, IV+IC (groups 2, 3; 43% positive)	0.44
12	IP-A	776-2E	13	All viruses, IC (groups 1, 2; 27% positive)	vs	All viruses, IV (groups 3, 4, 5, 6; 79% positive)	0.001
13		SVCPC	10
14		SVCPC-776	0
				All viruses, IP-A (groups 12, 13, 14; 65% positive)	vs	All viruses, IP-B (groups 15, 16, 17, 18, 19; 60% positive)	0.7
15	IP-B	776-2E	22	1E viruses, IP-A (groups 13, 14; 60% positive)	vs	1E viruses, IP-B (groups 18, 19; 64% positive)	0.86
16		VA45-54	6
17		776-VA	9
18		SVCPC	7
19		SVCPC-776	4
				2E viruses, IP-A (group 12; 69% positive)	vs	2E viruses, IP-B (groups 15, 16, 17; 59% positive)	0.53
SV40 neutralizing antibody
20	IC	776-2E	13	All viruses, IV+IC (groups 20, 21, 22, 23, 24, 25; 59% positive)	vs	All viruses, IP (groups 26, 27, 28, 29, 30; 15% positive)	<0.0001
21		SVCPC	13
22	IV	SVCPC	3	2E viruses, IV+IC (groups 20, 23, 24, 25; 50% positive)	vs	2E viruses, IP (groups 26, 29, 30; 16% positive)	0.003
23		VA45-54	2
24		776-VA	4
25		776-CPC	11
				1E viruses, IV+IC (groups 21, 22; 75% positive)	vs	1E viruses, IP (groups 27, 28; 12% positive)	<0.0001
26	IP (total)b	776-2E	29
27		SVCPC	18
28		SVCPC-776	7
29		VA45-54	2
30		776-VA	6
				2E viruses, IV+IC (groups 20, 23, 24, 25; 50% positive)	vs	1E viruses, IV+IC (groups 21, 22; 75% positive)	0.1
31	IP-A	776-2E	13	All viruses, IC (groups 20, 21; 42% positive)	vs	All viruses, IV (groups 22, 23, 24, 25; 80% positive)	0.01
32		SVCPC	10
33		SVCPC-776	3
				All viruses, IP-A (groups 31, 32, 33; 19% positive)	vs	All viruses, IP-B (groups 34, 35, 36, 37, 38; 11% positive)	0.37
34	IP-B	776-2E	16	1E viruses, IP-A (groups 32, 33; 15% positive)	vs	1E viruses, IP-B (groups 37, 38; 8% positive)	0.59
35		VA45-54	2
36		776-VA	6
37		SVCPC	8
38		SVCPC-776	4
				2E viruses, IP-A (group 31; 23% positive)	vs	2E viruses, IP-B (groups 34, 35, 36; 12% positive)	0.4

^aPercentage positive at 1:100 dilution.

^bIP (total), groups 7–11 and 26–30, are the combined totals of animals from the IP-A and IP-B experiments.