Table 6.
Comparison of the clinical laboratory findings in HLA allele or haplotype-positive and -negative hospitalized patients with hemorrhagic fever with renal syndrome.
| Characteristics | HLA-B*46-DRB1*09 positive | HLA-B*46-DRB1*09 negative | P | HLA-B*51-DRB1*09 positive | HLA-B*51-DRB1*09 negative | P | HLA-B*46 positive | HLA-B*46 negative | P |
|---|---|---|---|---|---|---|---|---|---|
| Mean age (year) | 44 (37–51) |
42 (39–44) |
0.428 | 46 (21–72) |
42 (40–44) |
0.334 | 43 (38–47) |
42 (39–44) |
0.360 |
| Mean course (days)a | 22 (17–27) |
19 (18–21) |
0.183 | 20 (12–29) |
20 (18–21) |
0.700 | 22 (18–25) |
19 (17–21) |
0.090 |
| Mean s-BUNmax (mmol/L) | 19.54 (11.06–28.02) |
20.57 (17.94–23.20) |
0.637 | 19.23 (4.41–42.88) |
20.49 (17.97–23.01) |
0.701 | 20.50 (14.32–26.69) |
20.39 (17.65–23.14) |
0.769 |
| Mean s-Creamax (μmol/L) | 596.01 (495.32–696.70) |
418.30 (360.51–476.09) |
0.011 | 690.02 (383.47–1004.60) |
430.13 (377.04–483.22) |
0.041 | 553.02 (469.03–637.00) |
410.19 (347.53–472.86) |
0.011 |
| Mean Leukmax (*109/L) | 16.69 (13.13–20.25) |
25.59 (21.05–30.13) |
0.275 | 18.06 (11.10–25.01) |
24.65 (20.48–28.82) |
0.798 | 24.55 (14.25–34.86) |
24.23 (19.93–28.52) |
0.797 |
| Mean PLTmin (*109/L)a | 48.36 (24.95–71.77) |
34.97 (20.37–29.57) |
0.073 | 43.00 (13.03–99.03) |
27.54 (22.35–32.74) |
0.334 | 39.33 (23.97–54.70) |
24.95 (19.99–29.91) |
0.087 |
| Mean s-ALBmin (g/L) | 30.36 (26.75–33.97) |
27.46 (26.03–28.90) |
0.125 | 30.03 (24.38–35.67) |
27.77 (26.38–29.15) |
0.451 | 28.98 (26.33–31.64) |
27.54 (25.99–29.10) |
0.766 |
The continuous variables were presented as mean (95% confidence interval). P value derived from the Mann-Whitney U test or the Student's t-test. S-BUNmax: highest blood urea nitrogen; S-Creamax: highest serum creatinine concentration; B-Leukmax: highest blood leukocyte count; B-Thrommin: lowest blood thrombocyte count; S-ALBmin: lowest serum albumin concentration (all measured during hospital care). Numbers in bold indicate an almost significant P value.
aThe days from fever onset to convalescence discharge from the hospital.