Table 3.

Log-linear results for the association between selected maternal folate metabolic genotypes and childhood acute lymphoblastic leukemia

Gene	RefSNP	RR1	95% CI	P-value2	Q-value3
BHMT	rs585800	0.49	0.27, 0.88	0.010	0.076
BHMT	rs558133	0.52	0.30, 0.90	0.011	0.076
BHMT	rs506500	0.56	0.33, 0.93	0.017	0.076
MTR	rs2282369	0.46	0.27, 0.80	0.004	0.076
MTR	rs4659745	0.51	0.30, 0.87	0.010	0.076
MTR	rs10802564	0.54	0.33, 0.90	0.012	0.076
MTR	rs10754584	0.51	0.29, 0.90	0.013	0.076
MTR	rs10733117	0.54	0.33, 0.90	0.013	0.076
MTR	rs2297965	0.55	0.33, 0.90	0.013	0.076
MTR	rs1050996	0.51	0.29, 0.91	0.014	0.076
MTR	rs12759827	0.46	0.23, 0.90	0.014	0.076
MTR	rs2385511	0.52	0.30, 0.91	0.015	0.076
MTR	rs3768150	0.52	0.30, 0.92	0.018	0.076
MTR	rs10802569	0.57	0.33, 0.96	0.025	0.094
MTR	rs3768142	0.58	0.34, 0.97	0.028	0.096
TYMS	rs699517	1.96	1.19, 3.21	0.005	0.076
TYMS	rs2612100	1.82	1.12, 2.95	0.011	0.076
TYMS	rs3786362	7.12	0.90, 56.00	0.017	0.076
TYMS	rs1004474	1.64	1.04, 2.58	0.023	0.091
TYMS	rs2847153	1.67	1.04, 2.69	0.026	0.094

¹RR estimates represent the increase or decrease in risk with each additional copy of the minor allele

²One-degree of freedom likelihood ratio test

³False discovery rate adjusted P-value