Table 2.
KSHV-encoded and KSHV-induced proteins involved in KS pathogenesis
| KSHV encoded protein or miRNA | Expression Type [119] | Oncogenic | Anti-Apoptotic | Immune Modulatory | Pro-inflammatory | Angiogenic |
|---|---|---|---|---|---|---|
| ORF73 (Lana-1) | Latent | X | X | |||
| ORF72 (vCyc) | Latent | X | X | X | ||
| ORF71 (vFlip) | Latent | X | ||||
| K12 (Kaposin A) | Latent/TPA Inducible | X | ||||
| ORF74 (vGPCR) | Lytic early | X | X | X | ||
| K1 | Lytic early and latent* | X | X | X | X | X |
| K9 (vIRF1) | Lytic early | X | X | X | ||
| K11/11.1 (vIRF2) | Lytic | X | ||||
| K10.5/10.6 (vIRF3 Lana-2) | Latent | X | X | |||
| ORF45 (tegument) | Immediate Early | X | ||||
| ORF50 (RTA) | Immediate Early | X | ||||
| K2 (vIL-6) | Lytic early and latent* | X | X | X | ||
| ORF4 (KCP) | Lytic late | X | ||||
| K3 (MIR1) | Immediate Early | X | ||||
| K5 (MIR2) | Immediate Early | X | ||||
| K8 (KbZIP) | Immediate Early | X | ||||
| K7 (vIAP) | Lytic late | X | ||||
| ORF16 (vBcl-2) | Lytic early | X | ||||
| K6, K4, K4.1 (vCCL-1,-2,-3) | Immediate Early | X | X | |||
| Kaposin B | Latent/TPA Inducible | ? | ||||
| miRK1-12 | Latent | X | X | X | X | X |
| KSHV induced protein | ||||||
| c-Kit | Cellular | X | ||||
| PDGF-R | Cellular | X | X | |||
| RDC1 (CXCR7) | Cellular | X | X | X | ||
| IL-6 | Cellular | X | X | |||
| MMPs | Cellular | X | X | |||
| Ang-2 | Cellular | X | ||||
| HIF1α, HIF1β | Cellular | X | ||||
| Cox-2 | Cellular | X | X | X |
*
Recent evidence suggests that K1 and vIL-6 mRNAs can also be detected latently [120]