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. 2012 Sep 11;8:609. doi: 10.1038/msb.2012.41

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Copyright © 2012, EMBO and Macmillan Publishers Limited

This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial Share Alike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.

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Simple model of cystic fibrosis (CF) of the lung. Left panel: interaction diagram, accounting for direct effects of CF on mucus dynamics. Right panel: model in the format of Biochemical Systems Theory (Savageau, 1976; Voit, 2000). For CF=0, the system has a steady state at about M=1.3, B=2.1, P=1.700, A=2.0, H=1600, D=6.3. Typical simulations, which start at the steady state or the corresponding steady state for CF=1, might reset the number of bacteria at certain time points, modeling responses to infections, or treatments like the removal of mucus or the infusion of antibiotics or anti-inflammatory cytokines (see Supplementary information for further details).