Table 2.

Side effects of first-line antituberculosis drugs

Drug	Major adverse effects	Rare adverse effects
Isoniazid	Peripheral neuropathy, skin rash, hepatitis, sleepiness and lethargy	Convulsions, psychosis, arthralgia, anemia
Rifampin	Gastrointestinal abdominal pain, nausea, vomiting, hepatitis, generalized cutaneous reactions, thrombocytopenic purpura	Osteomalacia, pseudo-membranous colitis, pseudo-adrenal crisis, severe renal stoppage, hemolytic blood paucity
Pyrazinamide	Arthralgia, hepatitis, gastrointestinal problems, eg, stomach upset, nausea, poor appetite and abdominal pain	Cutaneous reaction, sideroblastic anemia
Streptomycin	Vestibular and auditory nerve damage renal breakage, cutaneous allergic reaction	Pain, rash at injection site, numbness around the mouth and tingling soon after the injection
Thiacetazone	Skin rash that sometimes has mucosal involvement	Acute hepatic failure, exfoliative dermatitis

Reproduced with permission of the European Respiratory Society. Breathe. 2005;2:69–73.¹⁸