Table 3.

Side effects of second-line antituberculosis drugs

Drug	Major adverse effects	Rare adverse effects
Kanamycin	Vestibular (vertigo) and auditory nerve damage	Cutaneous hypersensitivity
Amikacin	Vestibular damage (vertigo) and auditory nerve damage	Clinical renal failure
Capreomycin	Nephrotoxicity
Ethionamide (prothionamide)	Gastrointestinal anorexia, nausea, diarrhea, abdominal pain, hepatotoxicity	Convulsions, mental symptoms, impotence, gynecomastia
Fluoroquinolones	Gastrointestinal anorexia, nausea, vomiting	Anxiety, dizziness, headache, convulsions, rupture of the Achilles tendon
Cycloserine	Dizziness, headache, depression, psychosis, convulsions	Suicide, generalized hypersensitivity, hepatitis
Para-aminosalicylic acid	Gastrointestinal anorexia, nausea, vomiting, hypersensitivity reactions (fever, rash, pruritus)	Hypothyroidism, hematological reactions

Reproduced with permission of the European Respiratory Society. Breathe. 2005;2:69–73.¹⁸