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. 2012 Aug 29;13(9):10771–10806. doi: 10.3390/ijms130910771

Table 1.

Examples of cross-resistance to stressors.

Stressor Cell Type/Organism Cross-Resistance Reference
H2O2 CHO cells Heat shock [143]
N-methyl-N-nitro-N-nitrosoguanidine (MNNG) [144]
γ-ray irradiation [144]
Human lymphocytes X-ray irradiation [145]

Heat CHO cells H2O2 [143]
Human skin fibroblasts Delayed aging [146]
Renal epithelial cells Cyanide [147]
C. elegans Increased lifespan [148]

Cold Drosophila melanogaster Heat stress [149,150]
Increased lifespan, delayed aging [150]

Chemicals
Xanthine and xanthine oxidase CHO cells H2O2 and γ-irradiation [144]
Rat hepatoma cells H2O2 and γ-irradiation [144]
2,4-dinitrophenol Rat brain cells Ischemia [151]
Dimethyl sulfoxide Hepatocytes Improved survival [152]

Exercise Rat skeletal muscle Oxidative stress [153]
Rat heart Ischemia [154]
Rats Delayed aging [155]
Ischemia [156,157]
Humans Delayed aging [158]
Ischemia [159]

Caloric restriction Aeromonas hydrophila Lowered temperature, sodium, and ethanol stresses [160]
Escherichia coli Heat stress and H2O2 [161]
Lactococcus lactis subsp. Lactis Heat, ethanol, acid, osmotic, and oxidative stresses [162]
Rhesus monkeys Delayed aging [163]
Humans Delayed aging [164]

Hypergravity Drosophyla sp. Thermotolerance [150]
Longevity, delayed aging [150,165]

Hydrostatic pressure Mouse blastocysts Improved survival [166]
Pig oocytes Improved survival [167,168]
Bull, boar spermatozoa Improved semen quality [169,170]

Shear forces Liver tissue Improved survival [171]