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Effects of cannabinoid 1 receptor (CB1) antagonist AM251 on mitragynine-induced antinociception (35 mg/kg). Each column represents the mean ± SEM of latency time (s) of six animals in each group. Values are statistically significant at a p < 0.05 compared to normal saline (vehicle control) and b p < 0.05 compared to THC alone group.
