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Effects of μ-opioid antagonist naloxone, δ-opioid antagonist naltrindole, μ1-opioid antagonist naloxonazine and κ-opioid antagonist norBNI on mitragynine-induced antinociception (35 mg/kg). Each column represents the mean ± SEM of latency time (s) for group of eight animals in each group. Values are statistically significant at p < 0.05. a p < 0.05 compared to mitragynine (35 mg/kg) alone group.
