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Inactivation and unfolding of psychrophilic enzymes. The activity of psychrophilic enzymes (upper panel, blue line) is inactivated by temperature before unfolding of the protein structure (lower panel, blue line) illustrating the pronounced heat-lability of the active site. By contrast, inactivation of mesophilic enzymes (black curves) closely corresponds to the loss of the protein conformation. Adapted from [14].
