Table 3.
Interactions of several lipid-related gene polymorphisms and overweight/obesity on blood pressure levels.
| SNP | Genotype | Normal weight | Overweight/obesity | ||||
|---|---|---|---|---|---|---|---|
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|
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| SBP | DBP | PP | SBP | DBP | PP | ||
| ABCA-1 V825I (rs2066715) | GG | 120.5 ± 15.9 | 75.4 ± 10.0 | 45.2 ± 11.2 | 125.5 ± 15.4 | 80.0 ± 10.1 | 45.6 ± 10.2 |
| GA | 118.8 ± 16.3 | 75.0 ± 9.6 | 43.8 ± 11.9 | 125.1 ± 16.5 | 79.6 ± 11.3 | 45.5 ± 11.4 | |
| AA | 120.9 ± 18.6 | 75.5 ± 9.2 | 45.5 ± 14.3 | 126.5 ± 20.1 | 80.1 ± 12.2 | 46.4 ± 13.4 | |
| F | 2.127 | 0.262 | 2.309 | 0.199 | 0.079 | 0.724 | |
| p | 0.120 | 0.770 | 0.100 | 0.820 | 0.924 | 0.485 | |
|
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| ACAT-1 (rs1044925) | AA | 130.6 ± 20.2 | 79.4 ± 10.6 | 51.2 ± 15.0 | 130.3 ± 18.3 | 83.5 ± 11.3 | 46.8 ± 12.5↓ |
| AC | 129.6 ± 19.0 | 79.7 ± 11.1 | 49.9 ± 15.3 | 135.1 ± 20.1↑ | 84.9 ± 13.9 | 50.2 ± 13.9 | |
| CC | 129.0 ± 25.5 | 79.8 ± 12.7 | 49.2 ± 24.9 | 123.5 ± 11.5↓ | 82.1 ± 12.7 | 41.5 ± 10.4↓ | |
| F | 0.338 | 0.112 | 1.048 | 5.825 | 1.289 | 5.910 | |
| p | 0.714 | 0.894 | 0.351 | 0.000 c | 0.276 | 0.000 c | |
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| LDL-R AvaII | A−A− | 118.0 ± 17.5 | 73.4 ± 9.8 | 44.5 ± 13.2 | 126.3 ± 16.7 | 80.5 ± 10.8↑ | 45.8 ± 11.7 |
| A−A+ | 118.1 ± 18.0 | 74.2 ± 9.3 | 43.9 ± 12.9 | 123.9 ± 17.3 | 79.2 ± 10.0 | 44.7 ± 11.4 | |
| A+A+ | 118.9 ± 17.1 | 74.9 ± 10.5 | 44.0 ± 11.2 | 124.7 ± 18.9 | 79.8 ± 13.7 | 45.0 ± 15.2 | |
| F | 0.142 | 1.420 | 0.340 | 2.249 | 4.276 | 0.538 | |
| p | 0.867 | 0.242 | 0.712 | 0.106 | 0.003 c | 0.548 | |
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| LIPC −250G > A (rs2070895) | GG | 117.1 ± 16.9 | 74.2 ± 9.3 | 42.9 ± 12.7 | 120.6 ± 16.9 | 77.8 ± 9.7 | 42.8 ± 13.1 |
| GA | 116.8 ± 15.8 | 73.8 ± 8.9 | 43.0 ± 12.3 | 123.8 ± 16.4↑ | 79.5 ± 10.4↑ | 44.3 ± 10.9 | |
| AA | 119.8 ± 19.2 | 74.3 ± 11.8 | 45.5 ± 13.5 | 129.7 ± 22.0↑ | 80.2 ± 12.6 | 49.5 ± 13.1 | |
| F | 1.347 | 0.299 | 1.685 | 4.233 | 3.125 | 2.367 | |
| p | 0.261 | 0.741 | 0.186 | 0.003c | 0.009 c | 0.094 | |
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| LIPG 584C > T (rs2000813) | CC | 117.8 ± 15.8 | 74.4 ± 9.5 | 43.37 ± 12.30 | 123.6 ± 13.9 | 78.2 ± 10.5 | 45.3 ± 10.5 |
| CT | 119.1 ± 17.0 | 75.3 ± 9.6 | 43.81 ± 12.60 | 126.8 ± 18.2 | 81.1 ± 11.0 | 45.7 ± 11.6 | |
| TT | 116.8 ± 16.2 | 76.0 ± 8.8 | 41.07 ± 10.72 | 121.5 ± 11.1 | 80.1 ± 10.9 | 41.4 ± 6.8 | |
| F | 1.214 | 1.452 | 1.261 | 0.920 | 2.408 | 0.087 | |
| p | 0.297 | 0.235 | 0.284 | 0.399 | 0.090 | 0.917 | |
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| MTHFR 677C > T (rs1801133) | CC | 113.7 ± 11.7 | 72.6 ± 7.5 | 41.1 ± 9.7 | 116.4 ± 10.9 | 74.8 ± 7.5 | 41.7 ± 9.3 |
| CT | 114.1 ± 11.9 | 73.0 ± 7.3 | 41.1 ± 9.5 | 118.1 ± 11.7 | 75.2 ± 6.6 | 43.0 ± 9.6 | |
| TT | 115.8 ± 10.5 | 73.4 ± 7.6 | 42.5 ± 10.4 | 116.8 ± 11.7 | 75.7 ± 7.6 | 42.6 ± 10.2 | |
| F | 1.057 | 0.604 | 0.660 | 1.312 | 0.005 | 1.186 | |
| p | 0.348 | 0.547 | 0.517 | 0.270 | 0.995 | 0.306 | |
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| MYLIP (rs3757354) | AA | 118.9 ± 16.3 | 75.5 ± 9.9 | 43.5 ± 11.8 | 125.5 ± 16.5 | 79.5 ± 9.9 | 46.0 ± 11.2 |
| AG | 120.8 ± 17.7 | 75.4 ± 10.0 | 45.4 ± 13.3 | 126.3 ± 17.9 | 81.5 ± 11.2 | 44.8 ± 12.0 | |
| GG | 118.4 ± 17.6 | 74.4 ± 10.0 | 44.1 ± 12.9 | 125.4 ± 18.0 | 79.9 ± 11.6 | 45.8 ± 12.8 | |
| F | 2.122 | 1.194 | 2.224 | 0.293 | 1.648 | 2.565 | |
| p | 0.120 | 0.303 | 0.109 | 0.746 | 0.193 | 0.077 | |
|
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| PCSK9 E670G (rs505151) | AA | 117.2 ± 16.3 | 74.2 ± 9.6 | 42.9 ± 12.0 | 124.2 ± 16.9 | 79.8 ± 11.0 | 44.4 ± 12.1 |
| AG | 116.0 ± 15.0 | 74.1 ± 8.1 | 41.8 ± 11.3 | 124.7 ± 13.1 | 82.2 ± 11.9 | 42.5 ± 6.4 | |
| F | 0.418 | 0.006 | 0.620 | 0.457 | 1.868 | 0.085 | |
| p | 0.518 | 0.938 | 0.431 | 0.499 | 0.172 | 0.770 | |
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| PPARD +294T > C (rs2016520) | TT | 120.0 ± 17.5 | 75.7 ± 10.1 | 44.4 ± 12.8 | 125.8 ± 18.3 | 79.9 ± 11.1 | 45.9 ± 13.3 |
| TC | 119.4 ± 16.6 | 74.6 ± 9.2 | 44.7 ± 12.1 | 123.5 ± 14.6 | 78.4 ± 8.9 | 45.1 ± 10.7 | |
| CC | 120.0 ± 21.3 | 75.5 ± 9.8 | 44.5 ± 15.5 | 125.9 ± 25.7 | 82.0 ± 17.4 | 43.9 ± 11.2 | |
| F | 0.207 | 1.301 | 0.088 | 0.629 | 0.858 | 0.703 | |
| p | 0.813 | 0.273 | 0.916 | 0.533 | 0.424 | 0.495 | |
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| SCARB1 (rs5888) | CC | 130.3 ± 19.3 | 81.2 ± 11.7 | 49.1 ± 14.7 | 132.4 ± 19.9 | 85.1 ± 12.0 | 47.3 ± 14.2 |
| CT | 131.1 ± 20.6 | 79.7 ± 11.5 | 51.4 ± 16.4 | 132.6 ± 19.1 | 83.6 ± 11.5 | 48.9 ± 13.8 | |
| TT | 131.7 ± 19.5 | 82.1 ± 12.6 | 49.6 ± 11.4 | 137.6 ± 21.2 | 78.6 ± 10.3 | 59.1 ± 19.8↑ | |
| F | 0.227 | 2.190 | 2.615 | 0.357 | 2.920 | 4.830 | |
| p | 0.797 | 0.112 | 0.074 | 0.700 | 0.054 | 0.002 c | |
SNP, single nucleotide polymorphism; SBP, systolic blood pressure; DBP, diastolic blood pressure; PP, pulse pressure; ABCA-1, ATP-binding cassette transporter A1; ACAT-1, acyl-CoA:cholesterol acyltransferase-1; LDL-R, low density lipoprotein receptor; LIPC, hepatic lipase gene; LIPG, endothelial lipase gene; MTHFR, methylenetetrahydrofolate reductase; MYLIP, the E3 ubiquitin ligase myosin regulatory light chain-interacting protein; PCSK9, proprotein convertase subtilisin-like kexin type 9; PPARD, peroxisome proliferator-activated receptor delta; SCARB1, Scavenger receptor class B type 1. The values of F and p of the overweight/obese subjects are the interactions between genotypes and overweight/obesity on blood pressure parameters. P c is the p-value after permutation correction. ↑, genotype and overweight/obesity interactions to increase blood pressure levels; ↓, genotype and overweight/obesity interactions to decrease blood pressure levels. Sex, age, education level, physical activity, alcohol consumption, cigarette smoking, and hyperlipidemia have been adjusted for the statistical analysis.