Table 4.
Correlation between genotypes or alleles and blood pressure levels in the normal weight and overweight/obese subjects.
| Blood pressure | Genotype/allele | Unstandardized coefficient | Std. error | Standardized coefficient | t | p |
|---|---|---|---|---|---|---|
| Total population | ||||||
|
| ||||||
| SBP | LIPC −250G > A genotype | 2.211 | 0.587 | 0.081 | 3.764 | 0.000 |
| LIPC −250G > A allele | 1.887 | 0.760 | 0.054 | 2.482 | 0.013 | |
| LIPG 584C > T allele | 1.799 | 0.737 | 0.053 | 2.414 | 0.016 | |
|
| ||||||
| DBP | LIPG 584C > T genotype | 1.396 | 0.403 | 0.077 | 3.460 | 0.001 |
| LIPG 584C > T allele | 1.734 | 0.466 | 0.083 | 3.718 | 0.000 | |
| PPARD +294T > C allele | −0.964 | 0.469 | −0.046 | −2.054 | 0.040 | |
| SCARB1 rs5888 genotype | −1.298 | 0.494 | −0.062 | −2.627 | 0.009 | |
| SCARB1 rs5888 allele | −1.530 | 0.564 | −0.064 | −2.711 | 0.007 | |
|
| ||||||
| PP | SCARB1 rs5888 genotype | 1.945 | 0.606 | 0.074 | 3.208 | 0.001 |
| SCARB1 rs5888 allele | 2.095 | 0.694 | 0.070 | 3.016 | 0.003 | |
|
| ||||||
| Overweight/obesity | ||||||
|
| ||||||
| SBP | ACAT-1 rs1044925 genotype | 2.884 | 1.277 | 0.079 | 2.259 | 0.024 |
| ACAT-1 rs1044925 allele | 4.816 | 1.443 | 0.116 | 3.338 | 0.001 | |
| LIPC −250G > A genotype | 4.317 | 0.933 | 0.154 | 4.629 | 0.000 | |
| LIPC −250G > A allele | 4.415 | 1.267 | 0.117 | 3.484 | 0.001 | |
| LIPG 584C > T allele | 2.850 | 1.166 | 0.085 | 2.444 | 0.015 | |
|
| ||||||
| DBP | LIPC −250G > A genotype | 1.444 | 0.579 | 0.086 | 2.493 | 0.013 |
| LIPC −250G > A allele | 1.938 | 0.782 | 0.085 | 2.478 | 0.013 | |
| LIPG 584C > T genotype | 2.167 | 0.671 | 0.112 | 3.232 | 0.001 | |
| LIPG 584C > T allele | 2.783 | 0.764 | 0.126 | 3.644 | 0.000 | |
| SCARB1 rs5888 genotype | −1.979 | 0.762 | −0.093 | −2.597 | 0.010 | |
| SCARB1 rs5888 allele | −1.788 | 0.856 | −0.075 | −2.089 | 0.037 | |
|
| ||||||
| PP | ACAT-1 rs1044925 allele | 2.651 | 0.941 | 0.093 | 2.816 | 0.005 |
| LIPC −250G > A genotype | 2.862 | 0.650 | 0.148 | 4.405 | 0.000 | |
| LIPC −250G > A allele | 2.414 | 0.882 | 0.093 | 2.736 | 0.006 | |
| SCARB1 rs5888 genotype | 2.989 | 0.884 | 0.117 | 3.383 | 0.001 | |
| SCARB1 rs5888 allele | 2.384 | 0.994 | 0.083 | 2.397 | 0.017 | |
SBP, systolic blood pressure; DBP, diastolic blood pressure; PP, pulse pressure; ABCA-1, ATP-binding cassette transporter A1; ACAT-1, acyl-CoA:cholesterol acyltransferase-1; LDL-R, low density lipoprotein receptor; LIPC, hepatic lipase gene; LIPG, endothelial lipase gene; MTHFR, methylenetetrahydrofolate reductase; MYLIP, the E3 ubiquitin ligase myosin regulatory light chain-interacting protein; PCSK9, proprotein convertase subtilisin-like kexin type 9; PPARD, peroxisome proliferator-activated receptor delta; SCARB1, Scavenger receptor class B type 1. Sex, age, education level, physical activity, alcohol consumption, cigarette smoking, and hyperlipidemia have been adjusted for the statistical analysis.