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. 2012 Jul 2;4(5-6):569–578. doi: 10.1159/000339149

Fig. 3.

Fig. 3

Cathelicidin expression is upregulated by vitD3 and downregulated by TNFα in sarcoidosis and healthy control alveolar macrophages. a Quantitative PCR analysis ofcDNA samples from sarcoidosis and healthy control alveolar macrophages cultured for 24 h in medium with or without vitD3 (10 nM). Values for cathelicidin mRNA were determined after normalization to GAPDH. Data are expressed as the fold change in cathelicidin mRNA expression relative to untreated cells (medium alone). n = 5 per group. * p < 0.05. b Cathelicidin-derived LL-37 peptide synthesis in supernatant fluids from sarcoidosis and healthy control alveolar macrophages cultured in vitro with or without vitD3. Data are normalized to untreated (medium) cultured cells. Controls: n = 4; sarcoidosis patients: n = 3. * p < 0.05. c A dot plot illustrates repression of alveolar macrophage cathelicidin mRNA expression by TNFα (250–500 units/ml) in sarcoidosis patients (n = 3) and healthy controls (n = 5). * p < 0.05.