| Host | Agent | Environment |
|---|---|---|
| Malnutrition | Pathogenic strains of Entamoeba histolytica with greater capacity for contact-dependent cytolysis, phagocytosis, proteolysis | Overcrowding |
| Vitamin deficiencies | Poor sanitation | |
| Alcoholism | Low socioeconomic status | |
| Immune suppression due to HIV/AIDS, malignancy, corticosteroid use, neonate status, pregnancy | ||
| Institutional living | ||
| Travel to an endemic region |
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