Table 2.

CRS-MIS is mediated by mutation of the sphingolipid biosynthesis pathway.

Strain/mutant	MIC (μg ml−1)		CRS-MIS fold differentiala	Mutation
	CSF	MCF
66032u	0.03	0.008	-	-
66032u-C1	0.5	0.00025	512	Fen1-N156D
66032u-C2	0.5	0.0005	256	Sur2-M1I
66032u-C3	0.5	0.001	128	Sur4-Y329stop
66032u-C4	1	0.002	128	Sur2-E299stop
66032	0.03	0.008	-	-
66032-C1	0.5	0.00025	512	Sur2-M197I
945	0.008	0.008	-	-
945-C1	0.25	0.001	256	Fen1-W145stop
945-C2	0.12	0.0005	256	Sur4-S141F
945-C3	0.06	0.0005	128	Fen1-P206L
945-C4	0.06	0.0005	128	Sur4-S141F
CE14	0.016	0.008	-	-
CE14-C1	0.25	0.0005	256	Fen1-W235stop
CE14-C2	0.25	0.001	128	Fen1-V255E
CE14-C3	0.25	0.001	128	Fen1-V255E
CE14-C4	0.12	0.0005	128	Sur4-K201E
CE08	0.016	0.008	-	-
CE08-C1	0.25	0.00025	512	Sur4-L144R
DSY753	0.016	0.008	-	-
DSY753-C1	0.5	0.0005	512	Fen1-E17stop
DSY753-C2	0.12	0.001	64	Sur2-N86K
2805615	0.008	0.008	-	-
2805615-C1	0.25	0.0005	512	Fen1-D166Y
2805615-C2	0.25	0.002	128	Ifa38-G214D
2807990	0.03	0.008	-	-
2807990-C1	0.5	0.001	128	Fen1-ΔI115-A138
Isolate 4771	0.25	0.001	-	Fen1-K175M
Isolate 4719	0.25	0.0005	-	Fen1-Y298stop
Isolate 4743	0.12	0.0005	-	Ifa38-I339M

^aRelative to wild-type parent, fold increase in CSF MIC x fold decrease in MCF MIC.