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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Mol Microbiol. 2012 Aug 22;86(2):303–313. doi: 10.1111/j.1365-2958.2012.08194.x

Table 2.

CRS-MIS is mediated by mutation of the sphingolipid biosynthesis pathway.

Strain/mutant MIC (μg ml−1)
CRS-MIS fold differentiala Mutation
CSF MCF
66032u 0.03 0.008 - -
66032u-C1 0.5 0.00025 512 Fen1-N156D
66032u-C2 0.5 0.0005 256 Sur2-M1I
66032u-C3 0.5 0.001 128 Sur4-Y329stop
66032u-C4 1 0.002 128 Sur2-E299stop
66032 0.03 0.008 - -
66032-C1 0.5 0.00025 512 Sur2-M197I
945 0.008 0.008 - -
945-C1 0.25 0.001 256 Fen1-W145stop
945-C2 0.12 0.0005 256 Sur4-S141F
945-C3 0.06 0.0005 128 Fen1-P206L
945-C4 0.06 0.0005 128 Sur4-S141F
CE14 0.016 0.008 - -
CE14-C1 0.25 0.0005 256 Fen1-W235stop
CE14-C2 0.25 0.001 128 Fen1-V255E
CE14-C3 0.25 0.001 128 Fen1-V255E
CE14-C4 0.12 0.0005 128 Sur4-K201E
CE08 0.016 0.008 - -
CE08-C1 0.25 0.00025 512 Sur4-L144R
DSY753 0.016 0.008 - -
DSY753-C1 0.5 0.0005 512 Fen1-E17stop
DSY753-C2 0.12 0.001 64 Sur2-N86K
2805615 0.008 0.008 - -
2805615-C1 0.25 0.0005 512 Fen1-D166Y
2805615-C2 0.25 0.002 128 Ifa38-G214D
2807990 0.03 0.008 - -
2807990-C1 0.5 0.001 128 Fen1-ΔI115-A138
Isolate 4771 0.25 0.001 - Fen1-K175M
Isolate 4719 0.25 0.0005 - Fen1-Y298stop
Isolate 4743 0.12 0.0005 - Ifa38-I339M
a

Relative to wild-type parent, fold increase in CSF MIC x fold decrease in MCF MIC.