Table 2. The effects of 2-heptanone and lidocaine on the isolated sciatic nerve of the rat.
Substance | Concentration | IT50 (seconds) | IT0 (seconds) | N |
2-heptanone | 10 mg/mL | 22.3±1.1 | 195±12 | 7 |
3.41 mg/mL | 39.14±4.84 | 221.88±7.32 | 12 | |
2.28 mg/mL | 108.9±0.22 | 358.8±18.07 | 4 | |
1.41 mg/mL | 109.7±2.87 | 517.5±25.62 | 4 | |
IC50 | 0.469 mg/mL (SEM±0.002) | |||
lidocaine | 10.0 mg/mL | 12.0±0.95 | 101.3±2.16 | 12 |
3.41 mg/mL | 27.11±3.16 | 147.50±9.96 | 12 | |
2.28 mg/mL | 30.9±0.22 | 186.8±8.07 | 6 | |
1.41 mg/mL | 32.23±3.16 | 320.3±14.96 | 6 | |
IC50 | 0.337 mg/mL (SEM±0.001). |