Table 4. Description of candidate mRNAs selected for further validation.
| Expression Levela | |||||
| Gene | BJAB Empty | BJAB BARTs | Fold Change | Predicted miRBARTs bindingsites in the 3′UTRb | Functions |
| CEBPA | 1.69 | 62.24 | 36.73 | 3, 15 | Transcription factor for cell growth and differentiation |
| TSPYL2 | 12.31 | 68.72 | 5.58 | 15, 5, 16, 19-3p, 7 | Regulation of G1 checkpoint of cell cycle |
| IPO7 | 104.82 | 538.57 | 5.14 | 3, 16 | Production of the proinflammatory cytokine IL-6; |
| A member of β-karyopherinfamily that imports proteinsinto the nucleus | |||||
| KISS1R | 1.46 | 5.77 | 3.95 | 14 | Receptor of KISS1 suppressor |
a
Expression level of mRNA was calculated using an algorithm as previously described (D. Vereide et al., manuscript submitted).
b
Predicted EBV miRNAs targeted to cellular mRNA were analyzed by PITA algorithms (26).
The mRNAs enriched in the immunoprecipitates of RISCs from BJAB BART relative to BJAB Empty cells were evaluated based on the criteria described. Candidates selected for further validation are listed with their predicted binding sites for EBV miRNAs and their assigned functions.