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. 2012 Oct 16;7(10):e47713. doi: 10.1371/journal.pone.0047713

Figure 1. Effect of HFD on macrophage infiltration and inflammation in the adipose tissue and the circulating proinflammatory cytokines in mice.

Figure 1

Male C57 BL/6J mice (4 weeks old) were fed LFD or HFD for 8 weeks. (A) Body weight (g) was measured. (B) Epididymal fat pad (% of body weight) was calculated. Plasmatic concentrations for (C) triglyceride (mg/dL), (D) total cholesterol (mg/dL), (E) fasting glucose (mg/dL), and (F) fasting insulin (mg/dL) were measured. (E) Concentration of circulating proinflammatory cytokines (pg/mL) were measured by ELISA. (H) mRNA expression levels in the adipose tissue were measured using real-time PCR. All values are indicated as the mean ± SEM (n = 10). *, p<0.05 and **, p<0.01 compared with LFD.