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. 2012 Oct 16;7(10):e47322. doi: 10.1371/journal.pone.0047322

Figure 4. OA treatment does not affect pre-ischemic cardiac function.

Figure 4

Isolated rat hearts were perfused under simulated hyperglycemic conditions (33 mM glucose) vs. controls (11 mM glucose) ±100 µM OA treatment. We initially perfused for 60 min, whereafter OA was added for a further 20 min. Subsequently, the buffer initially used was returned and hearts perfused for an additional 20 min. (A) Left ventricular developed pressure at baseline (11 mM) and (B) high glucose conditions (33 mM). Rate pressure product (RPP) at baseline (C) and (D) high glucose levels. Values are expressed as mean ± SEM (n = 9).