Table 2. Salivary IgG antibody levels (GMC; ng/ml) in children after 2 doses, 2+1-doses of PCV7 or no PCV7 vaccinations (controls) at the age of 12 and 24 months.
12 months | 24 months | |||||||
Controls | 2-dose | 2+1-dose | Controls | 2-dose | 2+1-dose | |||
Serotype | n = 60 | n = 54 | n = 63 | p-Values | n = 55 | n = 58 | n = 62 | p-Values |
4 | 1.8 | 11.3 | 124.0 | α, β, γ | 1.5 | 6.0 | 14.8 | α, β, γ |
6B | 4.4 | 12.7 | 188.2 | α, β, γ | 7.1 | 40.4 | 67.0 | β, γ |
9V | 2.6 | 18.7 | 177.9 | α, β, γ | 2.7 | 11.8 | 34.3 | α, β, γ |
14 | 3.1 | 49.7 | 360.3 | α, β, γ | 3.2 | 15.7 | 52.3 | α, β, γ |
18C | 1.1 | 11.5 | 137.3 | α, β, γ | 2.0 | 8.8 | 19.0 | α, β, γ |
19F | 11.2 | 33.8 | 147.2 | α, β, γ | 19.7 | 72.3 | 85.7 | β, γ |
23F | 1.2 | 8.2 | 112.4 | α, β, γ | 2.0 | 12.8 | 39.7 | α, β, γ |
1 | 4.6 | 3.0 | 3.7 | 4.3 | 4.1 | 5.7 | ||
3 | 1.2 | 1.3 | 0.7 | 1.0 | 1.4 | 1.5 | ||
5 | 8.6 | 7.3 | 9.1 | 11.2 | 10.7 | 12.9 | ||
7F | 5.1 | 3.3 | 3.5 | 4.2 | 3.1 | 5.3 |
α p-Values<0.05; 2+1 vs. 2-dose schedule.
β p-Values<0.05; 2+1-dose vs. controls.
γ p-Values<0.05; 2-dose vs. controls.
Calculated using log transformed unpaired t test, p-values are 2 sided.