Table 2.

Diagnostic Yield Characteristics

	Total (%)
Overall	45
Diagnosis by PLB	24 (53)
Diagnosis by secondary method	19 (42)
Lost to follow-up	2 (4)
Diagnosed by Percutaneous Lung Biopsy	24
Benign etiology
“Proven” fungal disease*	12 (26)
Bacterial infection	1 (2)
Atypical mycobacterial infection	1 (2)
Other benign#	1 (2)
Malignant etiology
Primary lung cancer	4 (9)
Metastatic disease	3 (7)
Post-transplant lymphoproliferative disease	1 (2)
Unknown primary	1 (2)
PLB Diagnosis by Type of Biopsy ‡
FNAB	9 (38)**
FNAB + CB	15 (71)**
Diagnosed by Secondary Method	19
Benign etiology
All invasive fungal disease*	8 (18)
“Proven” fungal disease	4 (9)
“Probable” fungal disease	1 (2)
“Possible” fungal disease	3 (7)
Bacterial infection	4 (9)
Atypical mycobacterial infection	1 (2)
Other benign#	3 (7)
Malignant etiology
Primary lung cancer	2 (4)
Lymphoma	1 (2)
Secondary Diagnostic Method	19
Surgical lung biopsy	7 (16)
Bronchoscopy	3 (7)
Clinical follow-up	6 (13)
Microbiologic culture (blood)	2 (4)
Fluid cytology (pleural)	1 (2)

^*: Based on EORTC/MSG criteria for diagnosis of fungal infections

^‡: FNAB: Fine Needle Aspiration biopsy, CB: Core biopsy

^**: Denominator based on biopsy type: FNAB, n=24; FNAB + CB, n=21

^#: Other benign etiology includes: fibrous tissue, old granulomatous disease