Table 2.

Prophylaxis testing results with P. berghei. The prepatent period was the average of days for all five mice tested per group. In all cases the drug was administered orally 1–3 hours prior to sporozoite injection, except where indicated by asterisk, where drug administration was six hours after infection. All dosing was in a suspension formulation of 0.5% w/v methylcellulose, 1% (v/v) solutol HS15.

	Dose mg/kg	Average Survival (%)	Prepatent Period (days)
Untreated	-	0	4
Untreated*	-	0	5.3
GNF179	5 p.o.	20	4.2
GNF179	15 p.o.	100	na
GNF179*	15 p.o.	80	6.2
GNF179	20 p.o.	100	na
Atovaquone	2.5 p.o.	100	na
Atovaquone*	2.5 p.o.	100	na
NITD609	30 p.o.	0	4.2
NITD609	15 p.o.	0	4.5

p.o., oral administration; na, not applicable due to lack of blood stage infection.