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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Birth Defects Res A Clin Mol Teratol. 2012 Sep 3;94(10):841–848. doi: 10.1002/bdra.23073

Figure 2. Failure of neural fold elevation in Hectd1opm mutant embryos is correlated with disorganized cranial mesenchyme.

Figure 2

The neural plate in E9.5 Hectd1opm mutant embryos does not transform from the biconvex to “V” then “C” shape demonstrating failure of neural fold elevation. The PM-CM in Hectd1opm mutant embryos fails to undergo the characteristic expansion seen in wildtype embryos and the PM-CM cells underlying the neural plate do not orientate parallel to the neuroepithelium.