Table 2.
n | 2-year PFS (%) (95% CI) |
p-value | 2-year OS (%) (95% CI) |
p -value | ||
---|---|---|---|---|---|---|
Overall | 54 | 9 (1,17) | 19 (7,31) | |||
Age | Age 17 years or younger | 29 | 14 (2,26) | 0.1 | 30 (12,48) | 0.07 |
Age 18 years or older | 25 | 4 (0,12) | 5 (0,15) | |||
Gender | Female | 26 | 4 (0,12) | 0.1 | 9 (0,21) | 0.1 |
Male | 28 | 14 (0,28) | 29 (9,49) | |||
Tumor Location | Thoracic | 31 | 3 (0,9) | 0.04 | 15 (1,29) | 0.1 |
Head/Neck | 19 | 16 (0,32) | 27 (2,52) | |||
Other Locations | 4 | 25 (0,68) | 25 (0,68) | |||
Tumor Histology | Carcinoma with Squamous Differentiation | 21 | 14 (0,30) | 0.4 | 33 (9,57) | 0.2 |
Carcinoma without Squamous Differentiation | 23 | 4 (0,12) | 6 (0,18) | |||
Other Histology | 9 | 11 (0,33) | 22 (0,49) | |||
NUT Translocation | BRD4-NUT | 38 | 8 (0,12) | 0.1 | 12 (0,24) | 0.4 |
BRD3-NUT | 3 | 0 | 33 (0,86) | |||
NUT-Variant | 12 | 17 (0,39) | 33 (6,60) | |||
Metastases | No Metastases | 21 | 19 (1,37) | 0.04 | 25 (3,37) | 0.1 |
Metastases | 32 | 3 (0,9) | 16 (2,26) | |||
Lymph Node Involvement | No Involvement | 29 | 10 (0,22) | 0.3 | 20 (2,38) | 0.3 |
Involvement | 25 | 8 (0,18) | 18 (2,34) | |||
Extent of Surgical Resection | Less than Gross Total | 10 | 10 (0,30) | 0.01 | 44 (7,81) | 0.03 |
Complete | 5 | 60 (17,100) | 80 (45,100) | |||
Less than Gross Total or No Surgical Resection | 49 | 4 (0,10) | 0.001 | 12 (0,24) | 0.002 | |
Complete | 5 | 60 (17,100) | 80 (45,100) | |||
Initial Radiotherapy | No | 27 | 0 | <0.0001 | 5 (0,15) | 0.0003 |
Yes | 26 | 19 (3,35) | 35 (13,57) | |||
Chemotherapy Regimen | Platinum-based | 33 | 9 (0,19) | 0.6 | 22 (4,40) | 0.3 |
Other | 20 | 10 (0,24) | 15 (0,31) | |||
Anthracycline/Alkylator-based | 17 | 18 (0,36) | 0.6 | 28 (4,40) | 0.4 | |
Other | 36 | 6 (0,14) | 15 (1,29) |
Abbreviation: CI (confidence interval)