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Establishment of a hypothyroid and TH replacement mouse model. Total serum T4 levels were measured by RIA after treatment with 0.1% MMI and 0.2% KClO4 and replacement with 20 ng/g T4 for 2–5 wk (A) or replacement with 0–500 ng/g T4 for 3 wk (B); n = 3–5 per group; *, P < 0.05; **, P < 0.01. ND, Not detectable.
