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. 2012 Jun 6;590(Pt 17):4255–4268. doi: 10.1113/jphysiol.2012.234856

Figure 3.

Figure 3

A, serum leptin level was significantly higher in HF-SED mice than that in LF-SED. Voluntary running during high-fat feeding opposed the development of the significant rise in serum leptin. B, circulating level of leptin normalized to total body fat mass (leptin/fat mass) was higher in HF-SED than in LF-SED. However, voluntary wheel running during high-fat feeding opposed the reduction in the leptin/fat mass ratio seen in high fat fed mice (HF-SED). C, the protein expression of leptin receptor (Ob-R) in coronary arterioles was significantly lower in HF-SED mice vs. LF-SED mice. Voluntary wheel running opposed the development of decreased leptin receptor protein in coronary arterioles of HF fed mice. Data are expressed as means ± SEM. *P < 0.05 vs. LF-SED, #P < 0.05 vs. HF-SED.