Table 1.
Characteristics of animals
| LF-SED | HF-SED | HF-RUN | |
|---|---|---|---|
| n | 11 | 11 | 10 |
| Body weight (g) | 23.84 ± 0.97 | 30.44 ± 1.72* | 24.55 ± 0.61# |
| % Body fat | 15.55 ± 2.50 | 41.75 ± 3.87* | 17.88 ± 1.11# |
| Fat mass (g) | 3.07 ± 0.57 | 13.58 ± 1.91* | 4.35 ± 0.34# |
| Lean mass (g) | 19.97 ± 0.69 | 16.75 ± 0.40* | 19.80 ± 0.43# |
| Insulin (ng ml−1) | 0.71 ± 0.18 | 1.40 ± 0.84 | 0.84 ± 0.17 |
| Blood glucose (mg dl−1) | 147.33 ± 13.05 | 171.33 ± 10.65 | 163.60 ± 9.23 |
| Red gastrocnemius | |||
| Citrate synthase activity (nmol μg−1 min−1) | 494.62 ± 39.88 | 547.38 ± 63.40 | 699.36 ± 47.84*# |
| Running distance (km daily) | 17.52 ± 0.85 |
Body weight, % body fat and fat mass were higher in HF-SED mice compared with LF-SED mice but they were significantly lower in HF-RUN mice than in HF-SED mice and comparable to LF-SED mice. Insulin and blood glucose level were not significantly different among groups. Citrate synthase activity was enhanced in red gastrocnemius of HF-RUN compared with LF-SED or HF-SED. Data are expressed as means ± SEM. *P < 0.05 vs. LF-SED, #P < 0.05 vs. HF-SED.