Table 2. Summary of Statistical Analysis of General Activity in 3-h Bins, Averaged Across 7 Days of Each of Weeks 1–4 Comprising Each Time Point of Interest.

Source	Week 1	Week 2	Week 3	Week 4
Baseline
Group main effect	NS	F2, 19=3.7, p=0.044a	F2, 21=3.86, p=0.037	NS
Group × time bin	NS	NS	NS	NS
0000–0300 h	NA	NS	NS	NA
0300–0600 h		NS	NS
0600–0900 h		NS	NS
0900–1200 h		NS	Cont>AMPH
1200–1500 h		NS	Cont>AMPH
1500–1800 h		NS	NS
1800–2100 h		NS	NS
2100–0000 h		NS	NS
6th Month of cumulative treatment
Group main effect	NS	NS	NS	NS
Group × time bin	NS	NS	NS	NS
First 4 weeks of the break
Group main effect	NS	F2, 19=4.19, p=0.031	NS	NS
Group × time bin	NS	F14, 133=2.98, p<0.001	NS	NS
0000–0300 h	NA	NS	NA	NA
0300–0600 h		NS
0600–0900 h		NS
0900–1200 h		Cont>Amph
1200–1500 h		Cont>AMPH; Cont>MPH
1500–1800 h		Cont>AMPH; Cont>MPH
1800–2100 h		Cont>Amph
2100–0000 h		NS
12th Month of cumulative treatment
Group main effect	NS	NS	NS	NS
Group × time bin	NS	NS	NS	NS
18th Month of Cumulative Treatment
Group main effect	NS	NS	NS	NS
Group × time bin	NS	NS	F14, 105=1.97, p=0.027	NS
0000–0300 h	NS	NS	NS	NS
0300–0600 h	NS	NS	NS	NS
0600–0900 h	NS	NS	Cont>AMPH; Cont>MPH	NS
0900–1200 h	NS	NS	NS	NS
1200–1500 h	NS	NS	NS	NS
1500–1800 h	NS	NS	Cont>AMPH; Cont>MPH	NS
1800–2100 h	NS	NS	NS	NS
2100–0000 h	NS	NS	NS	NS

Abbreviatons: NA, not applicable (post-hoc comparisons not conducted if no main effect and no interaction); NS, not significant.

^aPost-hoc comparisons of MPH and control and AMPH and control monkeys were not significant.