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. 2012 Aug 1;37(12):2624–2634. doi: 10.1038/npp.2012.123

Figure 1.

Figure 1

Behavioral responses of GABA-CB1-KO (left panels) and Glu-CB1-KO (right panels) male mice and their corresponding GABA-CB1-WT and Glu-CB1-WT mice, evaluated in the elevated plus-maze (EPM), treated either with vehicle or CP-55,940 (1 and 50 μg/kg). (a and b) Percentage of open arm (OA) entries (% of OAs=100 × open/(open+enclosed)) instead of absolute values in order to avoid any underlying interaction of treatment or genotype on the locomotion activity. (c and d) Total number of entries in open+enclosed arms. Data are presented as mean±SEM (8–10 animals per experimental group). Significant differences: *p<0.05 and **p<0.01 when compared with vehicles (same genotype) (one-way analysis of variance (ANOVA) followed by Bonferroni's test); §§§p<0.001 when compared with wild-type (WT) littermates (same treatment) (two-way ANOVA followed by Bonferroni's test).